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目的研究Krüppel样因子17(Krüppel-like factor 17,KLF17)在结直肠癌组织中的表达及其与患者临床病理特征及预后的关系。方法收集武汉市第一医院128例结直肠癌患者的临床病理资料,采用免疫组织化学法检测KLF17在结直肠癌及对应的非癌结直肠黏膜组织中的表达,Kaplan-Meier法绘制生存曲线,Cox比例风险模型进行生存分析。结果 128例结直肠癌中,83例癌组织存在KLF17低表达。KLF17低表达与结直肠癌患者淋巴结转移相关(P=0.012)。KLF17低表达患者5年无病生存率及总生存率分别为46.3%和49.3%,明显低于KLF17高表达患者的78.3%和82.0%(P均=0.001)。Cox模型分析结果显示:KLF17、术前肠梗阻、肿瘤分化程度和病理学N分期是结直肠癌患者无病生存时间及总生存时间的独立预后因素(P均<0.05)。结论 KLF17低表达与结直肠癌淋巴结转移相关,是结直肠癌患者预后不良的一个潜在分子指标。
Objective To study the expression of Krüppel-like factor 17 (KLF17) in colorectal cancer and its relationship with clinicopathological features and prognosis. Methods The clinical and pathological data of 128 patients with colorectal cancer in First Hospital of Wuhan City were collected. The expression of KLF17 in colorectal cancer and corresponding non-cancerous colorectal mucosa was detected by immunohistochemistry. The survival curve was drawn by Kaplan-Meier method. Cox proportional hazards model for survival analysis. Results Of the 128 cases of colorectal cancer, 83 cases of cancerous tissue had low KLF17 expression. Low expression of KLF17 was associated with lymph node metastasis in patients with colorectal cancer (P = 0.012). The 5-year disease-free survival and overall survival of patients with low expression of KLF17 were 46.3% and 49.3%, respectively, which were significantly lower than those of patients with high expression of KLF17 (78.3% vs 82.0%, P = 0.001). Cox model analysis showed that KLF17, preoperative intestinal obstruction, tumor differentiation and pathological N stage were independent prognostic factors of disease-free survival and overall survival in patients with colorectal cancer (all P <0.05). Conclusions The low expression of KLF17 is associated with lymph node metastasis of colorectal cancer and is a potential molecular marker of poor prognosis in patients with colorectal cancer.