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目的:探讨急性心肌梗死(AMI)患者发病早期至1周内血清抗心磷脂抗体(ACA)、D-二聚体(D-D)、血小板第4因子(PF4)的动态变化及其相互关系。方法:测定46例AMI患者发病24 h和1周时血清ACA、D-二聚体、PF4并与健康对照组40例比较。结果:AMI患者发病24 h血清ACA、D-二聚体、PF4分别为1.14±0.18、1.21±0.29、1.01±0.28、358.3±62.1、5.8±1.38及1周时ACA、D-D、PF4分别为1.24±0.25、0.98±0.11、0.96±0.29、386.1±45.2、6.92±1.41均明显高于对照组,且它们之间均有正相关性(P<0.01)。结论:AMI从发病早期至1周内ACA、D-D、PF4持续增高,表明自身抗体ACA、凝血因子D-D、PF4参与血栓的形成,早期应用血栓药物,可防止AMI的病情进展。
Objective: To investigate the dynamic changes of serum anti-cardiolipin antibodies (ACA), D-dimer (D-D) and platelet factor 4 (PF4) in patients with acute myocardial infarction (AMI) Methods: The serum levels of ACA, D-dimer and PF4 in 46 patients with AMI at 24 h and 1 week were measured and compared with 40 healthy subjects. Results: The ACA, D-dimer and PF4 in AMI patients were 1.14 ± 0.18, 1.21 ± 0.29, 1.01 ± 0.28, 358.3 ± 62.1 and 5.8 ± 1.38 respectively at 1 hour and 1.24 ± 0.25,0.98 ± 0.11,0.96 ± 0.29,386.1 ± 45.2,6.92 ± 1.41 were significantly higher than the control group, and there was a positive correlation between them (P <0.01). CONCLUSIONS: ACA, D-D and PF4 continue to increase in AMI from early onset to 1 week, indicating that autoantibodies ACA, coagulation factors D-D and PF4 are involved in the formation of thrombus. Thrombosis drugs can be used early to prevent progression of AMI.