论文部分内容阅读
本文通过小鼠30周氯化铝饮水染毒试验,证实饮水铝在4.4mg/L时,即可致小鼠脑铝有明显蓄积,脑AChE活性升高和病理学变化。这些变化均与动物饮水铝浓度有良好的剂量-效应关系。用曲线方程适度拟合法计算出饮水中铝浓度1.11mg/L时为预防动物脑铝蓄积的最大无作用浓度。由此,预防和控制过量的水溶性铝摄入是十分必要的。
In this paper, a 30-week exposure to aluminum chloride drinking water in mice demonstrated that a significant accumulation of cerebral aluminum and an increased activity of AChE in brain and pathological changes were observed in aluminum diets containing 4.4 mg / L of drinking water. All these changes have a good dose-effect relationship with animal drinking water aluminum concentration. Appropriate fitting of the curve equation to calculate the concentration of aluminum in drinking water 1.11mg / L to prevent the accumulation of brain animal brain maximum concentration of non-effect. Thus, prevention and control of excess water-soluble aluminum intake is very necessary.