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目的比较糖尿病及对照组患者血清肿瘤特异性生长因子(TSGF)水平,为糖尿病患者的早期肿瘤防治提供临床依据。方法 将60例糖尿病患者(糖尿病组)按糖化血红蛋白(HbA1c)水平分为3个亚组(每组20例):A组(HbA1c>11.1%),B组(HbA1c7.0%～11.0%),C组(HbA1c<7.0%),另选择20例健康体检者作为对照组。分别测定4组对象血清中TSGF水平并进行比较。结果糖尿病A、B、C3组TSGF水平均高于对照组(P均<0.05),A、B、C亚组TSGF水平呈依次递减(P<0.05)。结论糖尿病组患者TSGF水平与血糖控制水平高低有关,血糖控制越差TSGF越高,提示糖尿病血糖控制不佳可能增加罹患肿瘤的风险。
Objective To compare the levels of serum tumor specific growth factor (TSGF) in patients with diabetes mellitus and control subjects, and to provide a clinical basis for prevention and treatment of early cancer in diabetic patients. Methods Sixty diabetic patients were divided into 3 subgroups (HbA1c> 11.1%) according to HbA1c level: group A (HbA1c> 7.0% ~ 11.0%), group B , Group C (HbA1c <7.0%), and another 20 healthy subjects were selected as the control group. The serum levels of TSGF in four groups were measured and compared. Results The levels of TSGF in diabetic A, B and C3 groups were significantly higher than those in control group (P <0.05). The levels of TSGF in A, B and C subgroups were decreased in turn (P <0.05). Conclusion The level of TSGF in diabetic patients is related to the level of blood sugar control. The higher the blood glucose control is, the higher the TSGF, suggesting that the poor control of blood glucose may increase the risk of developing cancer.