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目的:观察复方地黄颗粒治疗女童特发性中枢性性早熟(ICPP)的临床疗效。方法:对50例ICPP女童予复方地黄颗粒治疗,疗程6个月,观察其临床疗效、治疗前后中医证候评分、乳核直径、子宫及卵巢容积、血清性激素(卵泡生成素FSH、黄体生成素LH、雌二醇E2)水平变化。结果:治疗显效23例,有效19例,无效8例,总有效率84%;治疗后中医证候评分、乳核直径、子宫及卵巢容积、血清性激素水平较治疗前明显降低,治疗前后比较差异有统计学意义(P<0.01或P<0.05)。结论:复方地黄颗粒能降低特发性中枢性性早熟女童性激素水平,有效控制和减缓性腺发育的成熟程度和进度,临床疗效肯定。
Objective: To observe the clinical efficacy of Compound Dihuang Granules in the treatment of idiopathic central precocious puberty (ICPP) in girls. Methods: Fifty ICPP girls were treated with Rehmanniae Granules for 6 months. The clinical curative effect, TCM syndrome score, core diameter, uterus and ovary volume, serum sex hormones (follicle stimulating hormone FSH, luteinizing hormone LH, estradiol E2) levels change. Results: 23 cases were cured, 19 cases were effective and 8 cases were ineffective. The total effective rate was 84%. After treatment, TCM syndrome score, milk core diameter, uterine and ovarian volume, serum sex hormone levels were significantly lower than before treatment, before and after treatment There was statistical significance (P <0.01 or P <0.05). Conclusion: Dihuang Granule can reduce the level of sex hormones in idiopathic precocious puberty girls and effectively control and slow down the maturation and progress of gonadal development. The clinical curative effect is certain.