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抵达高原的最初数日,通气增强尚不能达到最大限度,在此阶段正是急性高山病(包括高原肺水肿)发病率最高的时期;同时临床上观察到高原肺水肿敏感的人,对缺氧的通气反应降低是个重要因素。膈肌是通气的主要动力来源,因此观察大白鼠膈肌麻痹后对高原肺水肿发生的影响。体重200克左右的雌性和雄性大白鼠76只,部分动物在乙醚麻醉下,切断靠近第6和第7颈椎旁的右侧和双侧膈神经,从而引起右侧和双侧膈肌麻痹。手术后动物在常温常压室内饲养24小时,然后随机共分6组:正常动物的平原和高原组、右侧膈肌麻痹的平原和高原组、双侧膈肌麻痹的平原和高原组。高原组均连续经受模拟3000米高原48小时。
At the first few days of reaching the plateau, the enhancement of aeration can not reach the maximum limit, which is the period of the highest incidence of acute mountain sickness (including high altitude pulmonary edema). In the meantime, The reduction in ventilatory response is an important factor. Diaphragmatic ventilation is the main source of power, so to observe the rats after diaphragm paralysis on the impact of altitude pulmonary edema. A total of 76 female and male rats weighing 200 grams were anesthetized with ether to excise the right and bilateral phrenic nerves near the 6th and 7th cervical parasagits to cause paralysis of the right and left diaphragms. After surgery, the animals were housed for 24 hours at room temperature and pressure, and then randomly divided into 6 groups: plain and plateau group of normal animals, plain and plateau group of right diaphragm paralysis, plain and bipolar group of bipolar paralysis. Plateau groups were continuously subjected to simulated 3000-meter plateau for 48 hours.