根据环氧化酶、５脂氧化酶活性中心结构模型设计了一组β芳胺酮类化合物，并用胺交换反应合成了这些化合物．经红外光谱、核磁共振氢谱及元素分析证实了８ 个未见文献报道的化合物的结构．药理实验结果显示．部分受试化合物在巴豆油诱发小鼠足趾肿胀模型中表现出一定的抗炎活性． According to cyclooxygenase, 5-lipoxygenase activity center structure model designed a group of β  aromatic amines ketones and amine exchange reaction of these compounds. The structures of eight compounds that have not been reported in the literature were confirmed by IR, 1H NMR and elemental analysis. Pharmacological experimental results show. Some of the tested compounds showed certain anti-inflammatory activity in the croton oil-induced mouse toe swelling model.