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四、发病机理1.感染及毒素沙眼衣原体是沙眼的致病原因当无疑义。但其发病机理近年才渐阐明。沙眼衣原体只感染结膜上皮细胞,在沙限刮片中从不在吞噬细胞内见有包涵体。Taverne 等的实验证明,沙眼衣原体如被吞噬细胞吞噬后则失去活力,同时吞噬细胞亦被破坏。但在上皮细胞内沙眼衣原体则生长繁殖,并且主要是在含溶酶体之酸性磷酸酶(Lyso-somal acid phosphatase)较少的上皮细胞内。沙眼衣原体的感染虽只限局子结膜上皮细胞,但沙眼的病变则广泛深入,不仅在上皮下有
Fourth, the pathogenesis 1. Infection and toxins Chlamydia trachomatis is the cause of trachoma when no doubt. However, its pathogenesis only gradually clarified in recent years. Chlamydia trachomatis is only infected with conjunctival epithelial cells, and in the sand-limiting scraps, there is no evidence of inclusion in phagocytes. Experiments by Taverne et al. Demonstrated that C. trachomatis loses its viability after being phagocytosed by phagocytes and that phagocytic cells are also destroyed. Chlamydia trachomatis in the epithelial cells grow and multiply, and mainly in epithelial cells containing less lysosomal acid phosphatase (Lyso-somal acid phosphatase). Chlamydia trachomatis infection, although only the sub-conjunctival epithelial cells, but trachoma lesions are extensive in depth, not only in the subcutaneous