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为探讨一氧化氮（ Ｎ Ｏ） 在脑梗塞患者中的作用，应用荧光分光光度法测定１５ 例脑梗塞患者和１０ 例对照组脑脊液中 Ｎ Ｏ 的浓度，同时测量脑梗塞体积并对神经机能缺损程度进行评分。结果发现：脑梗塞患者脑脊液中 Ｎ Ｏ 浓度较对照组明显升高（ Ｐ ＜ ０ ．０５） ； Ｎ Ｏ 浓度与脑梗塞体积大小呈正相关（ ｒ ＝ ０ ．５７ ， Ｐ ＜ ０ ．０５ ） ，与神经机能缺损程度亦呈正相关（ ｒ ＝ ０ ．５４ ， Ｐ ＜ ０ ．０５ ） 。本结果支持脑缺血后产生的 Ｎ Ｏ可加重缺血性脑损害。
To investigate the role of nitric oxide (N O) in cerebral infarction, the concentration of N 0 in cerebrospinal fluid in 15 patients with cerebral infarction and 10 patients in control group was measured by fluorescence spectrophotometry. The volume of cerebral infarction was measured and the neurological deficits Degree of grading. The results showed that the concentration of NO in cerebrospinal fluid of patients with cerebral infarction was significantly higher than that of the control group (P <0.05); the concentration of NO was positively correlated with the volume of cerebral infarction (r = 0.57, P <0.05), and Neurological deficit was also positively correlated (r = 0.54, P <0.05). The results support N O produced after cerebral ischemia can aggravate ischemic brain damage.