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目的:探究氨氯地平联合卡维地洛治疗晨峰高血压疗效。方法:选取2015年2月至2016年8月贵阳市云岩区人民医院收治的150例晨峰高血压患者进行研究,将上述患者随机分为两组,对照组接受卡维地洛治疗,观察组接受氨氯地平联合卡维地洛治疗,比较两组患者血压控制情况与不良反应情况。结果:(1)治疗前两组患者收缩压、舒张压比较,差异均无统计学意义(P>0.05),治疗后两组患者白天收缩压与舒张压、夜间收缩压与舒张压、24 h平均血压收缩压与舒张压以及晨峰高收缩压与舒张压值均显著优于治疗前水平,差异均具有统计学意义(P<0.05)。观察组晨峰高血压控制率88.0%,对照组晨峰高血压控制率60.0%,组间比较,差异具有统计学意义(P<0.05)。(2)两组患者均未出现严重并发症,两组患者不良反应情况比较,差异无统计学意义(P>0.05)。结论:氨氯地平联合卡维地洛治疗晨峰高血压疗效显著。
Objective: To investigate the efficacy of amlodipine and carvedilol in treating morning peak hypertension. Methods: From January 2015 to August 2016, 150 cases of CHD patients with hypertension in Yunyan District People’s Hospital of Guiyang were selected and randomly divided into two groups. The control group received carvedilol treatment and observed Group received amlodipine combined with carvedilol treatment, compared two groups of patients with blood pressure control and adverse reactions. Results: (1) There was no significant difference in systolic pressure and diastolic pressure between the two groups before treatment (P> 0.05). After treatment, systolic and diastolic blood pressure, systolic and diastolic blood pressure at night, Mean systolic blood pressure and diastolic blood pressure and morning systolic blood pressure and diastolic blood pressure were significantly better than pre-treatment levels, the differences were statistically significant (P <0.05). In the observation group, the peak hypertension control rate was 88.0% in the observation group and that in the control group was 60.0% in the morning peak hypertension control group. The differences between the two groups were statistically significant (P <0.05). (2) No serious complications occurred in both groups. There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion: Amlodipine combined with carvedilol is effective in treating morning peak hypertension.