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目的分析雌激素或孕激素受体阳性即单激素受体阳性乳腺癌患者的临床病理特征及预后因素,比较两种单激素受体阳性即ER单阳性和PR单阳性乳腺癌患者的不同之处。方法2000年9月至2002年9月在我院就诊的Ⅰ~ⅢC期单激素受体阳性乳腺癌患者共112例,分析其临床病理特征及预后因素。结果全组患者5年生存率(OS)为89.0%,5年无病生存率(DFS)为79.8%。COX多因素预后分析显示,腋窝淋巴结转移数目是全组患者的独立预后因素(P=0.003),脉管瘤栓是淋巴结阴性单激素受体阳性患者DFS的独立预后因素(P=0.038)。PR单阳性组年龄≤50岁(P=0.021)以及绝经前患者(P=0.033)显著多于ER单阳性组。PR单阳性组分级3级、肿瘤直径>2 cm、脉管瘤栓者的比例略高于ER单阳性组,但无统计学意义。内分泌治疗可显著改善ER单阳性组患者的OS(P=0.04)及DFS(P=0.000)。内分泌治疗有一定程度上提高了PR单阳性组患者的OS(P=0.271)及DFS(P=0.387)。结论腋窝淋巴结转移数目是全组患者的独立预后因素。内分泌治疗可显著改善ER单阳性组患者的生存,有改善PR单阳性组患者生存的趋势。
Objective To analyze the clinicopathological features and prognostic factors of estrogen or progesterone receptor-positive patients with single hormone receptor-positive breast cancer and to compare the differences between the two single-hormone receptor-positive patients with ER single positive and PR single-positive breast cancer . Methods One hundred and twelve patients with stage Ⅰ ~ ⅢC single hormone receptor positive breast cancer who were treated in our hospital from September 2000 to September 2002 were analyzed. Their clinicopathological features and prognostic factors were analyzed. Results The 5-year overall survival (OS) was 89.0% and the 5-year disease-free survival (DFS) was 79.8%. Multivariate Cox regression analysis showed that axillary lymph node metastasis was an independent prognostic factor in all patients (P = 0.003). Vascular thrombus was an independent predictor of DFS in patients with node-negative single hormone receptor (P = 0.038). PR single positive group less than 50 years of age (P = 0.021) and premenopausal patients (P = 0.033) was significantly more than ER single positive group. PR single positive group level 3, tumor diameter> 2 cm, the proportion of vascular tumor suppository was slightly higher than the ER single positive group, but not statistically significant. Endocrine therapy significantly improved OS (P = 0.04) and DFS (P = 0.000) in ER single positive patients. Endocrine therapy increased OS (P = 0.271) and DFS (P = 0.387) in patients with PR single positive group to a certain extent. Conclusions The number of axillary lymph node metastases is an independent prognostic factor in all patients. Endocrine therapy can significantly improve the survival of patients with ER single positive group, there is a trend to improve the survival of patients with single positive PR group.