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目的了解细胞因子及一氧化氮（ＮＯ）在脑出血病理过程中的作用及相互关系。方法对２３例脑出血患者分别于发病后４ｈ、１２ｈ、２４ｈ、３ｄ和７ｄ时测定白介素－６（ＩＬ－６）、肿瘤坏死因子α（ＴＮＦα）及ＮＯ的血清浓度，将每项的每个时相值同正常对照间、不同时相间以及不同项目间进行配对ｔ检验、方差分析及相关分析。结果ＩＬ－６呈逐渐升高再逐渐下降的规律；ＴＮＦα呈一个急剧升高较快降低的趋势；ＮＯ呈一双峰模式。在超早期ＩＬ－６与ＴＮＦα间、ＴＮＦα与ＮＯ间有相关性。结论ＴＮＦα及ＩＬ－６相继表达可能诱导脑出血后最初的炎性免疫损伤。ＮＯ与ＴＮＦα互相影响共同参与脑出血的病理过程。
Objective To investigate the role of cytokines and nitric oxide (NO) in the pathogenesis of intracerebral hemorrhage and their relationship. Methods Serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and NO were measured in 23 patients with cerebral hemorrhage at 4h, 12h, 24h, 3d and 7d after onset of symptoms. Paired t test, analysis of variance and correlation analysis were used to compare the time phase values with normal control, different time phases and different items. The results showed that IL-6 was gradually increased and then decreased gradually; TNFα showed a rapid increase and decreased rapidly; NO showed a bimodal pattern. In the early stage of IL-6 and TNFα, there is a correlation between TNFα and NO. Conclusion The sequential expression of TNFα and IL-6 may induce the initial inflammatory injury after intracerebral hemorrhage. NO and TNFα influence each other to participate in the pathological process of cerebral hemorrhage.