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目的:探讨脑钠肽对糖耐量减低患者合并冠心病影响及对冠状动脉狭窄程度的预测作用。方法:126例糖耐量减低患者均行冠状动脉造影术,分为冠状动脉正常组31例,单支病变组35例,双支病变组32例,3支病变组28例,并发冠心病者按临床类型分为稳定型心绞痛组(30例)、不稳定型心绞痛组(33例)和急性心肌梗死组(32例),所有患者检测脑钠肽浓度,比较各组脑钠肽水平。结果:急性心肌梗死组的脑钠肽水平明显高于其他3组(P<0.01),不稳定型心绞痛组脑钠肽水平高于稳定型心绞痛组及对照组(P<0.01),稳定型心绞痛组脑钠肽虽高于冠状动脉正常组,但差异无统计学意义(P>0.05),随着冠状动脉狭窄程度的加重,脑钠肽水平逐渐上升,冠状动脉病变各组与冠状动脉正常组比较,差异有统计学意义(P<0.01),双支病变组与单支病变组,3支病变组与双支病变组比较,差异均有统计学意义(P<0.01)。结论:脑钠肽可预测糖耐量减低患者并发冠心病,其水平随冠状动脉狭窄程度增加而升高。
Objective: To investigate the effect of brain natriuretic peptide (BNP) on coronary heart disease (CAD) and the degree of coronary artery stenosis in patients with impaired glucose tolerance. Methods: 126 patients with impaired glucose tolerance underwent coronary angiography, divided into normal coronary artery group of 31 cases, 35 cases of single vessel disease group, 32 cases of double vessel disease group, 3 lesions of 28 cases, patients with coronary heart disease by The clinical type was divided into stable angina group (30 cases), unstable angina group (33 cases) and acute myocardial infarction group (32 cases). All the patients were tested for brain natriuretic peptide concentration, and the levels of brain natriuretic peptide in each group were compared. Results: The levels of brain natriuretic peptide in acute myocardial infarction group were significantly higher than those in the other three groups (P <0.01). The levels of brain natriuretic peptide in unstable angina pectoris group were higher than those in stable angina pectoris group and control group (P <0.01) The brain natriuretic peptide group was higher than the normal coronary artery group, but the difference was not statistically significant (P> 0.05). With the severity of coronary artery stenosis, the level of brain natriuretic peptide increased gradually. The coronary artery lesion group and normal coronary artery group (P <0.01). The difference between the double-vessel disease group and the single-vessel disease group, the three-vessel disease group and the double-vessel disease group was statistically significant (P <0.01). Conclusion: Brain natriuretic peptide can predict coronary heart disease in patients with impaired glucose tolerance and its level increases with the degree of coronary artery stenosis.