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目的:探讨戊型肝炎病毒在慢性重型乙型肝炎(慢重乙肝)发病中的作用和对预后的影响。方法:回顾性分析102例慢重乙肝重叠戊型肝炎(慢重乙肝重叠戊肝)病例的临床表现和预后,并与同期100例慢重乙肝进行比较。结果:慢重乙肝重叠戊肝与慢重乙肝的病死率(11.8%比28.0%)、肝昏迷发生率(33.3%比54.0%)和腹水发生率(52.9%比78.0%)的差异均有统计学意义,P<0.05。结论:慢重乙肝重叠戊肝的预后较单纯慢重乙肝好,可能与戊型肝炎病毒感染为加重乙肝病变的一过性损伤有关。当戊型肝炎病程过后,病情加重之诱因消除,则较易恢复。
Objective: To explore the role of hepatitis E virus in the pathogenesis of chronic severe hepatitis B (chronic severe hepatitis B) and the impact on prognosis. Methods: The clinical manifestations and prognosis of 102 cases of chronic hepatitis B with overlapping hepatitis E were retrospectively analyzed and compared with 100 cases of chronic hepatitis B during the same period. Results: There was statistical difference between the mortality of patients with chronic hepatitis B and those with chronic hepatitis B (11.8% vs 28.0%), hepatic coma (33.3% vs 54.0%) and ascites (52.9% vs 78.0%) Significance, P <0.05. Conclusions: The prognosis of patients with chronic hepatitis B overlapped with hepatitis E is better than those with simple chronic hepatitis B, which may be related to the transient damage caused by hepatitis E virus infection. When the duration of hepatitis E, the incentive to exacerbate the disease is eliminated, it is easier to recover.