Load-Unload Response Ratio (LURR) is a new promising approach to earthquake prediction. In the previous years, a series of successful medium-term predictions have been made for strong earthquakes on the Chinese mainland using this method. In order to investigate whether the LURR method applies to different tectonic regimes, i.e., whether it is universal, the San Andreas Fault and its vicinities are chosen as the study region in this paper. The spatial variation of LURR in the western United States (30°～50°N, 100°～130°W) is studied in detail and the earthquake tendency in this region is discussed based on historic earthquake cases. Load the Unload Response Ratio (LURR) is a new promising approach to earthquake prediction. In the previous years, a series of successful medium-term predictions have been made for strong earthquakes on the Chinese mainland using this method. In order to investigate whether the The San Andreas Fault and its vicinities are chosen as the study region in this paper. The spatial variation of LURR in the western United States (30 ° -50 ° N, 100 ° ~ 130 ° W) is studied in detail and the earthquake tendency in this region is is based on historic earthquake cases.