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目的临床和人群研究提示,脱氢表雄酮和它的硫酸盐在抗动脉粥样硬化和冠心病中起保护作用。然而,这种作用的机制仍不清楚。最近报道,硫酸脱氢表雄酮通过增加一氧化氮的生成来延缓动脉粥样硬化的形成。方法24岁的男性受试者(年龄65.4±0.7岁;范围58.2~67.6岁)经盲法安慰剂对照研
Objectives Clinical and population studies suggest that DHEA and its sulfates have protective effects against atherosclerosis and coronary heart disease. However, the mechanism of this effect remains unclear. It has recently been reported that DHEA delays the development of atherosclerosis by increasing nitric oxide production. Methods A 24-year-old male subject (age 65.4 ± 0.7 years; range 58.2 to 67.6 years) was blindly placebo-controlled