目的探讨中西医结合治疗系膜增生性肾小球肾炎（ＭｓＰＧＮ）疗效。方法对比观察了中西医结合（治疗组）与单纯西药（对照组）治疗经肾活检诊断的ＭｓＰＧＮ的临床疗效。结果治疗组完全缓解率和总有效率为５８．８％和９０６％，显著高于对照组的２２５％和６２５％（Ｐ＜００５），而治疗组复发率仅３５％，明显低于对照组２２５％（Ｐ＜００５）。结论在常规西药治疗基础上，辩证配合中药是治疗ＭｓＰＧＮ的有效方法之一。 Objective To investigate the curative effect of mesotherapy and mesotherapy on mesangial proliferative glomerulonephritis (MsPGN). Methods The clinical efficacy of MsPGN diagnosed by renal biopsy in the combination of traditional Chinese and western medicine (treatment group) and western medicine alone (control group) was observed. Results The complete remission rate and total effective rate were 58.8% and 90.6% in the treatment group, which were significantly higher than those in the control group (225% and 625%, P <005) 35%, which was significantly lower than that of the control group (225%, P <005). Conclusion On the basis of conventional western medicine, dialectical cooperation with traditional Chinese medicine is one of the effective ways to treat MsPGN.