Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astrocytomaformation,which might reveal new potential targets for glioma therapeutic drug design,we used the B8-RAS-transgenic mouse astrocytoma model.Using multiplex gene expression profiling,we found that growth-associated Previous molecular analyzes of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression. In an effort to identify novel gene expression changes associated with astrocytomaformation, which might reveal new potential targets for glioma therapeutic drug design, we used the B8- RAS-transgenic mouse astrocytoma model. Using multiplex gene expression profiling, we found that growth-associated