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目的探讨急性坏死性胰腺炎（ANP）对心肾损伤的影响。方法采用3.5％牛磺胆酸逆行注射胰胆管建立鼠的ANP模型。观察炎性介质内毒素、淀粉酶、磷脂酶A2，白细胞介素（IL－）1、肿瘤坏死因子x（TNFα）的变化和生长抑素的作用。结果ANP可以诱导炎性介质的明显升高，并与心肾损伤的严重程度呈正相关。而生长抑素能抑制ANP的炎性介质过度表达，减轻心肾损伤的程度。结论炎性介质参与了ANP对心肾器官的损伤，生长抑素对ANP的心肾损伤有治疗价值。
Objective To investigate the effect of acute necrotizing pancreatitis (ANP) on heart and kidney injury. Methods The rat model of ANP was established by retrograde injection of pancreaticobiliary fluid with 3.5% taurocholic acid. To observe the changes of endotoxin, amylase, phospholipase A2, interleukin (IL-) 1, tumor necrosis factor x (TNFα) and somatostatin in inflammatory mediators. Results ANP could induce a significant increase of inflammatory mediators and was positively correlated with the severity of heart-kidney injury. Somatostatin can inhibit the inflammatory mediators ANP overexpression, reduce the extent of heart and kidney damage. Conclusions Inflammatory mediators are involved in the injury of heart and kidney in rats with ANP. Somatostatin has therapeutic value on heart and kidney damage of ANP.