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目的 :探讨 P5 3蛋白和增殖细胞核抗原 ( PCNA)在口腔粘膜扁平苔癣 ( OLP)中的表达情况。方法 :采用免疫组织化学方法检测 P5 3蛋白及 PCNA在 OLP和口腔鳞癌 ( OSCC)中的表达情况。结果 :P5 3蛋白和 PCNA在正常口腔粘膜及糜烂型 OLP中表达阴性 ;在糜烂型 OLP和 OSCC中表达阳性。结论 :糜烂型 OLP的 P5 3蛋白和 PCNA的表达高于非糜烂型 OLP,癌变危险性较大
Objective: To investigate the expression of P53 protein and proliferating cell nuclear antigen (PCNA) in oral lichen planus (OLP). Methods: Immunohistochemistry was used to detect the expression of P53 protein and PCNA in OLP and oral squamous cell carcinoma (OSCC). Results: P53 protein and PCNA were negative in normal oral mucosa and erosive OLP, and positive in erosive OLP and OSCC. Conclusion: The expression of P53 protein and PCNA in erosive OLP is higher than that in non-erosive OLP, and the risk of canceration is higher