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①目的探讨妊娠期活动性人巨细胞病毒（ＨＣＭＶ）感染与免疫抑制的关系。②方法对３５例活动性ＨＣＭＶ感染孕妇的细胞免疫、体液免疫功能指标进行测定，并与２６例正常孕妇进行了比较。③结果感染孕妇血清ＩｇＭ总量为２．４９±０．１７ｇ／Ｌ，正常孕妇为２．００±０．２８ｇ／Ｌ，差异具有显著性（ｔ＝２．２５８，Ｐ＜０．０５）；其它体液免疫指标如补体Ｃ３含量、血清ＩｇＧ，ＩｇＡ含量两组之间差异无显著性（ｔ＝０．４３９～１．００９；Ｐ均＞０．０５）。Ｔ淋巴细胞亚群在感染孕妇主要表现为ＣＤ４阳性细胞绝对数的减少及ＣＤ４／ＣＤ８比值下降或倒置。而两组孕妇血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）比较，差异无显著性（ｔ＝０．８８５，Ｐ＞０．０５）。④结论活动性ＨＣＭＶ感染孕妇免疫功能的异常主要表现为细胞免疫功能的抑制。
Objective To investigate the relationship between HCMV infection and immunosuppression during pregnancy. Methods The cellular immunity and humoral immune function of 35 pregnant women with active HCMV infection were measured and compared with 26 normal pregnant women. Results The total amount of serum IgM was 2.49 ± 0.17g / L in pregnant women and 2.00 ± 0.28g / L in normal pregnant women, the difference was significant (t = 2.258, P <0.05). Other indicators of humoral immunity such as complement C3 content, serum IgG, IgA content between the two groups showed no significant difference (t = 0.439 ~ 1.009; P all> 0.05). T lymphocyte subsets in pregnant women infected with the main performance of the absolute number of CD4-positive cells decreased and CD4 / CD8 ratio decreased or inverted. Serum soluble interleukin-2 receptor (sIL-2R) was not significantly different between the two groups (t = 0.885, P> 0.05). ④ Conclusion The abnormal immune function of pregnant women infected with active HCMV is mainly manifested as the inhibition of cellular immune function.