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目的 :分析停经天数、术前血 β -HCG浓度对输卵管妊娠腹腔镜下保守性手术后发生持续性异位妊娠(PEP)的影响。方法 :选择 1 994年 1 2月～ 2 0 0 0年 1 2月在我院住院的输卵管妊娠患者 1 51例 ,给以腹腔镜下行输卵管开窗取胚术。手术前及术后每 3d～ 7d检测 1次血 β -HCG直至正常。用精确概率法及卡方检验 ,分析停经天数、术前血 β -HCG浓度对PEP的影响。结果 :1 51例输卵管妊娠患者中发生PEP6例 ,发生率3 .97%。停经 40d～ 60d者PEP的发生率 1 .0 1 % ,停经 (40d者的发生率 9.677% ,停经 >60d者的发生率9.52 %。停经 (40d和 ) 60d者PEP的发生率均高于停经 40d～ 60d者 ,且其差异均有显著意义 (均P <0 .0 5)。而未发生PEP者与PEP者术前血 β -HCG的差异无统计学意义 (P >0 .0 5)。结论 :PEP的发生与停经天数有关 ,而与术前血 β -HCG浓度无关。停经少于 40d或大于 60d者 ,发生率较高 ,停经 40d～ 60d者发生率较低。
Objective: To analyze the effect of menopause days and preoperative blood β-HCG concentration on persistent ectopic pregnancy (PEP) after laparoscopic conservative surgery in tubal pregnancy. Methods: One hundred and ninety-five cases of tubal pregnancy hospitalized in our hospital from January 1994 to February 2000 were selected for laparoscopic salpingo-oophorectomy. Blood β-HCG levels were measured at 1 day before operation and after operation every 3 to 7 days until normal. The exact probability method and chi-square test were used to analyze the effect of premenopausal days and preoperative serum β-HCG concentration on PEP. Results: PEP was found in 51 cases of tubal pregnancy, with a rate of 3.97%. The incidence of PEP was (P <0.01) after menopause (40d-60d), the incidence of PEP was (9.677% after 40d, 9.52% after menopause> 60d) 40d ~ 60d, and the differences were significant (all P <0.05), while there was no significant difference in preoperative blood β-HCG between PEP and PEP (P> 0.05) .Conclusion: The incidence of PEP is related to the days of menopause, but not to the preoperative serum β -HCG concentration.The incidence of menopause less than 40 days or more than 60 days is higher, and the incidence of menopause 40 days to 60 days is lower.