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目的评价α-硫辛酸治疗糖尿病周围神经病变(DPN)的疗效及安全性。方法70例DPN患者随机分为2组,2组均在控制血糖稳定后开始观察,对照组给予甲钴胺注射液500μg+生理盐水100 ml静脉滴注,1次/d;治疗组给予α-硫辛酸注射液300 mg+生理盐水100 ml静脉滴注,1次/d。2组疗程均为30 d。观察临床症状、体征、比较治疗前后运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)等指标的改变。结果治疗组总有效率与对照组比较差异有统计学意义(P<0.05),治疗组各项神经传导速度与对照组比较差异有统计学意义(P<0.05)。两组治疗期间均无明显不良反应。结论α-硫辛酸治疗糖尿病周围神经病变安全有效。
Objective To evaluate the efficacy and safety of α-lipoic acid in the treatment of diabetic peripheral neuropathy (DPN). Methods Seventy patients with DPN were randomly divided into two groups. The two groups were observed after the control of blood glucose was stable. The control group was given mecobalamin 500μg saline + 100 ml intravenous infusion once a day. The treatment group was given α- Octanoic acid injection 300 mg + saline 100 ml intravenously, 1 time / d. The two courses of treatment were 30 d. The clinical symptoms and signs were observed. The changes of motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) were compared before and after treatment. Results The total effective rate in the treatment group was significantly different from that in the control group (P <0.05). The nerve conduction velocity in the treatment group was significantly different from that in the control group (P <0.05). No significant adverse reactions during the two groups during treatment. Conclusion α-lipoic acid is safe and effective in the treatment of diabetic peripheral neuropathy.