甲苯二异氰酸酯(Toluene diisocyanate,TDI)是一种重要的低分子量工业生产原料。它包括2,4-甲苯二异氰酸酯与2,6-甲苯二异氰酸酯80∶20的混合物(简称TDI 80)及65∶35的混合物(TDI 65)两种工业产品,最常用的是TDI 80。其主要用于聚氨酯泡沫的生产,也用于油漆、涂料和胶黏剂等[1]。TDI其主要的生物学特性是它的刺激性和致敏潜能,能够降低肺功能,引起职业性哮喘[2]。TDI还会引起遗传损伤,遗传物质的损伤也是介导TDI各种毒性的机制之一。在 Toluene diisocyanate (TDI) is an important low-molecular weight industrial raw material. It includes two industrial products, 80:20 mixture of 2,4-toluene diisocyanate and 2,6-toluene diisocyanate (TDI 80) and 65:35 mixture (TDI 65), the most commonly used being TDI 80. It is mainly used in polyurethane foam production, but also for paints, coatings and adhesives [1]. TDI’s main biological properties are its irritant and sensitizing potential, its ability to reduce lung function and cause occupational asthma [2]. TDI can also cause genetic damage, damage to genetic material is also one of the mechanisms mediating various toxicities of TDI. in