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现已确定应用极低热量液体配方饮食能治疗肥胖。但许多患者在用该饮食几周后体重减轻速度减慢,一些患者在6～12周后体重减轻完全停止。为了观察生理剂量的三碘甲腺原氨酸(T_3)和低热量饮食一起是否会影响早期体重减轻的速度和是否会消除或减少后期的体重停滞不降现象,作者进行了双盲试验。 受试者按性别和身高均超过其理想体重的25％(最初体重为80～128公斤)。除1例妇女外,所有患者曾用1000大卡的饮食均未能使体重减轻。由内分泌异常引起的肥胖,高血压或心脏病患者不包括在本试验中。患者每天供给320大卡(1.34M-J)的液体配方饮食,含有31克蛋白质,45克碳水化合物,1.5克脂类,重要的维生素和矿物质,包括140微克碘。无热量饮料可随意饮用。给随机选择的患者服三碘甲腺原氨酸,开始二周内其剂量递增,由每天20微克(一片)增至20微克一天三次。
It has been determined that the application of very low calorie liquid diet can treat obesity. However, many patients lose weight after a few weeks with this diet, and some patients completely stop losing weight after 6 to 12 weeks. To examine whether physiological doses of triiodothyronine (T_3) combined with a low-calorie diet affect the rate of early weight loss and whether elimination or reduction of late weight loss does not decrease, the authors conducted a double-blind trial. Subjects were more than 25% of their ideal body weight by sex and height (initial weight 80-128 kg). With the exception of 1 woman, all patients had lost weight with a 1000 kcal diet. Patients with obesity, hypertension or heart disease due to endocrine abnormalities are not included in this study. The patient drank 320 calories (1.34M-J) a day in a liquid formula diet containing 31 grams of protein, 45 grams of carbohydrates, 1.5 grams of fat, vital vitamins and minerals, including 140 micrograms of iodine. No calorie drinks are free to drink. Triiodothyronine was administered to randomly selected patients starting with their dose escalation starting from 20 micrograms (one tablet) daily to 20 micrograms three times a day for the first two weeks.