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目的：研究山莨菪碱对移植肾术后并发症的治疗作用。方法：肾移植术后３２人。术后１４人未发生少尿时ｉｖ山莨菪碱４７±ｓ１２（３０～６０）ｍｇ／ｄ，连续给药７．１±２．９ｄ（４～１０ｄ）（预防组）。术后１８人出现少尿时ｉｖ山莨菪碱９１±２７（６０～１２０）ｍｇ／ｄ、呋塞米与免疫抑制剂（治疗组）。结果：预防组多尿期缩短１～３ｄ，２４ｈ尿量明显少于治疗组，血肌酐达正常值较治疗组提前１．５ｄ，无继发少尿或无尿。治疗组亦全部恢复正常，肾功能达显效所需时间为２．５±１．０ｄ（１～４ｄ）。结论：山莨菪碱具有改善和保护移植肾功能，预防和治疗移植肾术后出现的少尿或无尿的作用。
Objective: To study the therapeutic effect of anisodamine on postoperative complications of transplanted kidney. Methods: 32 patients after renal transplantation. 14 cases of postoperative oliguric iv anisodamine iv ± s12 (30 ~ 60) mg / d, continuous administration of 7.1 ± 2.9d (4 ~ 10d) (prevention group). 18 patients after oliguric iv iv anisodamine 91 ± 27 (60 ~ 120) mg / d, furosemide and immunosuppressive agents (treatment group). Results: The polyuria in prevention group shortened 1 ~ 3d, 24h urine output was significantly less than the treatment group, serum creatinine up to normal 1.5d earlier than the treatment group, no secondary oliguria or anuria. The treatment group also returned to normal, the effective time of significant renal function 2.5 ± 1.0d (1 ~ 4d). Conclusion: Anisodamine can ameliorate and protect renal graft function and prevent and treat oliguria or anuria after transplantation.