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糖尿病肾病(DN)进展至终末期肾病是一系列进程不断发展的结果,其中最重要的是逐渐和不可逆的肾小球瘢痕形成,称为肾小球硬化症。过去几年,对导致DN的致病因素的了解已取得很大进展。糖尿病肾病肾小球硬化症是由细胞外基质(ECM)蛋白在肾小球系膜间隙积聚,导致弥漫性或结节性纤维化。最常见的基质蛋白是胶原蛋白Ⅰ、Ⅲ、Ⅳ和纤维连接蛋白。这些积聚物是由于肾小球系膜细胞合成增加或系膜基质金属蛋白酶降解减少所致。20多年前已阐明了
Diabetic nephropathy (DN) The progression to end-stage renal disease is the result of a series of processes that progress, the most important of which is progressive and irreversible glomerular scarring, known as glomerulosclerosis. In the past few years, great progress has been made in understanding the causal factors responsible for DN. Diabetic nephropathy Glomerulosclerosis is the accumulation of extracellular matrix (ECM) proteins in the mesangial space of the glomeruli, resulting in diffuse or nodular fibrosis. The most common matrix proteins are collagen I, III, IV and fibronectin. These accumulations are due to increased mesangial cell synthesis or decreased mesangial matrix metalloproteinase (MMP) degradation. More than 20 years ago has been clarified