灰黄霉素,是一种抗真菌的抗菌素,Oxford等在1939年从P.griseofulvum的菌丝体里得到。为了大量制备,近来多趋向于采用深层发酵的方法。深层发酵的关键在于产生分生孢子的条件,而孢手的诱发可用下列方法: 1)培养到一定时候将菌丝滤出,转移到通气的情况下。 2)加入钙、铜或粗葡萄糖。 3)将干燥的菌丝转移到无氮的培养基上。 Griseofulvin, an antifungal antibiotic, was obtained by Oxford et al. from P.griseofulvum mycelium in 1939. For large-scale preparation, more recent methods tend to use deep fermentation. The key to deep fermentation is the production of conidial conditions. The induction of spores can be done in the following ways: 1) The hyphae are filtered out after a certain period of time and transferred to aeration. 2) Add calcium, copper or crude glucose. 3) Transfer the dried mycelium to nitrogen-free medium.