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急性白血病(AL)是威胁人类健康的主要恶性肿瘤之一,化学药物治疗是其主要的治疗手段之一。临床化疗失败的一个重要原因是肿瘤细胞对化疗药物产生耐药性。大多数肿瘤患者的死因与耐药直接或间接有关。根据肿瘤细胞耐药谱的不同,可分为原药耐药(primary drug resistance,PDR)和多
Acute leukemia (AL) is one of the major malignant tumors that threaten human health. Chemotherapy is one of the main treatments. An important reason for the failure of clinical chemotherapy is that tumor cells are resistant to chemotherapeutic drugs. The cause of death in most cancer patients is directly or indirectly related to resistance. According to the difference of tumor cell resistance spectrum, it can be divided into primary drug resistance (PDR) and multiple