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棉酚为一颇有前途的男用节育药,但在某些地区,眼药者可偶发低血钾症,且其发生率远较对照人群高,从而表明,棉酚与低血钾症有一定关系。在低钾饲养大鼠,棉酚可导致骨骼肌细胞内失钾,而在常规饲养动物则否,提示低钾摄入可能为棉酚所致钾代谢障碍的协同因子。我们在低钾环境条件下观察了棉酚对离体骨骼肌钾含量的影响,现报道如下。方法与结果取体重80 g 左右雄性大鼠8只,随机分为2组,即棉酚组及对照组,每组4只,方法按
Gossypol is a promising male sterility medicine, but in some areas, ocular ejaculation may occur occasionally, and its incidence is far higher than the control population, indicating that gossypol and hypokalemia are A certain relationship. Gossypol can cause the loss of potassium in skeletal muscle cells in low-potassium fed rats, but not in the conventional feeding animals, suggesting that low potassium intake might be a synergistic factor for the potassium metabolism disorder caused by gossypol. We observed the effect of gossypol on the potassium content in isolated skeletal muscle under hypoxic conditions, and are reported below. Methods and Results Eight male rats weighing 80 g were randomly divided into 2 groups: gossypol group and control group, 4 in each group.