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Objective:To observe the effects of Chinese decoction and ligustrazin hydrochloride injection combined with He-Ne laser on lipoperoxide (LPO) and Superoxide dismutase (SOD) in patients with chloasma.Methods:90 cases of chloasma were randomly divided into the following two groups:a treatment group (of 54 cases) treated by a self-prepared prescription for toning the kidneys and relieving the depressed liver to remove blood stasis, ligustrazin hydrochloricde injection and He-Ne laser therapy, and a control group (of 36 cases) treated with oral administration of Vitamin E and Vitamin C plus extal application of 20% Azelaic acid cream.Results:The total effective rate in the treatment group was 79.6%, which was significantly higher than that of the control group (P＜0.05).After treatment, the LPO level in the treatment group was significantly lowered (P＜0.01), and the SOD level was significantly elevated (P＜0.05).Conclusion:The therapeutic methods adopted in the treatment group may show the action of antioxidation, providing good clinical effects for treating chloasma.