目的了解广西河池市2008～2012年手足口病流行特征,为制定防控措施提供科学依据。方法采用描述性流行病学方法对河池市2008～2012年手足口病疫情监测资料进行分析。结果 2008～2012年河池市共报告手足口病30 701例,年均发病率为165.16/10万;重症病例年均发病率为1.43/10万,其病死率为10.94%。各县(市、区)病例报告超过1 000例,3～7月为发病高峰期(占71.45%)。农村散居儿童是手足口病高危人群,≤5岁的病例最多(占95.66%),男性发病高于女性(P<0.01)。重症病例、普通病例标本EV71型病毒核酸检测阳性率分别为93.81%、29.62%,重症病例发生率与EV71型病毒核酸阳性率呈正比例关系。结论目前河池市手足口病疫情形势仍严峻,特别要加强农村地区手足口病的防控。 Objective To understand the epidemiological characteristics of hand-foot-mouth disease in Hechi of Guangxi from 2008 to 2012 and provide a scientific basis for making prevention and control measures. Methods Descriptive epidemiological methods were used to analyze the epidemic situation of HFMD in Hechi from 2008 to 2012. Results A total of 30 701 HFMD cases were reported in Hechi City from 2008 to 2012, with an average annual incidence of 165.16 / 100 000. The annual average incidence of severe cases was 1.43 per 100 000 and the case fatality rate was 10.94%. More than 1,000 cases were reported in all counties (cities and districts), and the peak was from March to July (71.45%). Children living in rural areas were at high risk of hand-foot-mouth disease, with the largest number of cases ≤5 years (95.66%) and the incidence of male being higher than that of females (P0.01). In severe cases and common cases, the positive rates of nucleic acid detection of EV71 virus were 93.81% and 29.62% respectively. The incidence of severe cases was positively correlated with the positive rate of EV71 virus nucleic acid. Conclusion At present, the epidemic situation of hand-foot-mouth disease in Hechi City is still serious, especially prevention and control of hand-foot-mouth disease in rural areas.