在肿瘤的基因研究过程中,人们力致寻找一种正常体细胞很少表达或不表达,而在肿瘤细胞却大量表达的基因。正常细胞与肿瘤细胞生物学行为最大的区别在于后者可以无限制生长,而前者有丝分裂到一定程度就会衰老死亡。近十几年的研究表明人类大多数恶性肿瘤细胞中有端粒酶活性.从而维持染色体两端端粒的完整性使肿瘤细胞无限生长。本章旨在探讨端粒酶活性与肿瘤进展及预后的关系。 In the process of tumor gene research, people are desperately looking for a gene that is rarely expressed or expressed in normal somatic cells but expressed in large quantities in tumor cells. The difference between normal cells and biological behavior of tumor cells is that the latter can grow indefinitely, while the former mitosis to a certain extent will die of aging. Nearly ten years of research have shown that most human malignant tumor cells have telomerase activity in order to maintain the integrity of telomere ends of the chromosome so that tumor cells grow indefinitely. This chapter aims to investigate the relationship between telomerase activity and tumor progression and prognosis.