肠球菌是致病性低的革兰阳性人体正常菌群 ,具有先天耐药性 ,也容易被诱导产生新的耐药性 ,在过去十年中 ,临床上出现了耐万古霉素的肠球菌 ,常引起致死感染 ,治疗极为困难。本文就其耐药机制、起源、危险因素、治疗和预防方面作一综述 ,有利于临床工作者对VRE的感染进行预防和控制 Enterococcus is a low-pathogenic gram-positive human normal flora, with innate resistance, but also easily lead to new resistance, in the past decade, clinically vancomycin-resistant enterococci , Often cause fatal infection, the treatment is extremely difficult. This article reviews the mechanisms of resistance, origin, risk factors, treatment and prevention, which are helpful for clinicians to prevent and control VRE infection