目的探讨pN0食管鳞癌nm23、E-cadherin表达与淋巴结微转移的关系。方法采用Evision免疫组化法检测86例pN0食管鳞癌根治术后原发灶nm23、E-cadherin表达,以AE1/AE3为微转移指标检测淋巴结,分析nm23、E-cad-herin表达与淋巴结微转移的关系。结果 86例pN0期食管鳞癌区域淋巴结通过AE1/AE3免疫组化染色,发现31例(36.0%)有淋巴结微转移,并且淋巴结微转移与肿瘤分化程度和浸润深度有密切联系(P﹤0.05);nm23、E-cadherin在pN0期食管鳞癌原发灶表达阳性率分别为65.1%,67.4%,淋巴结微转移与nm23、E-cadherind的表达呈负相关(P﹤0.01)。结论 pN0期食管鳞癌原发灶nm23、E-cadherin表达缺失是淋巴结微转移的高危因素,两者联合检测有望成为评估微转移风险有用指标。 Objective To investigate the relationship between the expression of nm23, E-cadherin and lymph node micrometastasis in pN0 esophageal squamous cell carcinoma. Methods The expression of nm23 and E-cadherin in primary tumor of 86 esophageal squamous cell carcinoma of the esophagus were detected by Evision immunohistochemistry. The expression of nm23, E-cad-herin and lymph node micrometastasis were analyzed by AE1 / AE3 as micrometastasis markers Transfer of the relationship. Results Twenty-six cases (36.0%) had lymph node micrometastasis in 86 cases of esophageal squamous cell carcinoma of pN0 by AE1 / AE3 immunohistochemical staining, and lymph node micrometastasis was closely associated with the degree of tumor differentiation and depth of invasion (P <0.05) ; The positive expression rate of nm23 and E-cadherin in pN0 esophageal squamous cell carcinoma was 65.1% and 67.4%, respectively. The lymph node micrometastasis was negatively correlated with the expression of nm23 and E-cadherin (P <0.01). Conclusion The lack of expression of nm23 and E-cadherin in pN0 esophageal squamous cell carcinoma is a risk factor for micrometastasis of lymph nodes. The combined detection of nm23 and E-cadherin may be a useful indicator to evaluate the risk of micrometastasis.