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无脑儿、脊柱裂等异常妊娠的羊水中,在组织培养的条件下,可含有大量的“快速贴瓶细胞”(称为RA细胞)。该细胞的起源尚未证实。本文用免疫荧光法研究表明这些细胞起源于神经胶质。这种细胞在羊水中的出现,为诊断无脑儿等属于先天性神经管缺陷的胎儿提供了可靠的依据。作者为一位已确诊怀有无脑儿的孕妇(初产妇);有长期服用苯妥英钠等抗惊厥药物的服药史;妊娠20周时母体血清甲胎蛋白含量异常性升高;超声波检查异常;对羊水中甲胎蛋白含量大于正常值的五十个标准差以上的羊水细胞作了检查。即先将羊水细胞
Absence of brain, spina bifida and other abnormal pregnancy in amniotic fluid, under the conditions of tissue culture, can contain a large number of “quick paste bottle cells” (called RA cells). The origin of this cell has not been confirmed. In this study, immunofluorescence studies showed that these cells originated in glia. The appearance of this kind of cells in amniotic fluid provides a reliable basis for the diagnosis of fetuses without congenital defects of neural tube. The author is a pregnant woman who has been diagnosed with brainlessness (primipara); has taken medication history of anticonvulsant drugs such as phenytoin for a long time; abnormally increased level of alpha-fetoprotein in maternal serum at 20 weeks’ gestation; abnormalities in sonography; Amniotic fluid cells in the amniotic fluid content of alpha-fetoprotein greater than the standard of fifty standard amniotic fluid cells were examined. The first amniotic fluid cells