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目的:高血压合并高脂血症患者应用不同剂量辛伐他汀的临床疗效与安全性。方法:择取我院在2015年3月8日收取的70例患者作为研究对象,按数字奇偶法分为2组,各35例,对照组给予小剂量辛伐他汀进行治疗,实验组给予大剂量辛伐他汀进行治疗,观察两组患者临床疗效以及不良反应发生情况。结果:实验组临床疗效为94.28%,明显高于对照组82.57%,差异对比(p<0.05);实验组治疗后血脂水平降低显著优于对照组,改善明显,数据对比存在统计学意义(p<0.05);实验组不良反应发生率为11.43%,对比对照组8.57%,无明显差异(p>0.05)。结论:给予大剂量辛伐他汀治疗高血压合并高脂血症,疗效较小剂量更加显著,不良反应无显著差异,值得临床推广应用。
Objective: The clinical efficacy and safety of different doses of simvastatin in patients with hypertension and hyperlipidemia. Methods: Seventy patients admitted to our hospital on March 8, 2015 were enrolled in this study. They were divided into two groups (n = 35) according to the digital parity method. The control group was given low-dose simvastatin for treatment. The experimental group The dose of simvastatin for treatment, two groups of patients observed the clinical efficacy and adverse reactions. Results: The clinical curative effect of the experimental group was 94.28%, which was significantly higher than that of the control group (82.57%, p <0.05). The decrease of blood lipid level in the experimental group was significantly better than that of the control group, with significant improvement <0.05). The incidence of adverse reactions in the experimental group was 11.43%, compared with 8.57% in the control group, no significant difference (p> 0.05). Conclusions: Given high dose of simvastatin in the treatment of hypertension and hyperlipidemia, the effect of smaller doses is more significant, and there is no significant difference in adverse reactions, which is worthy of clinical application.