目的探讨亚临床甲状腺功能减退(SCH)与冠心病的相关性。方法选择冠心病并接受选择性冠状动脉造影患者211例。分别列入甲状腺功能正常组48例和SCH组163例。根据冠状动脉造影结果分别列入冠状动脉造影阴性组,冠状动脉单支病变、双支病变、三支或左主干病变组。比较各组患者的基本资料,冠状动脉狭窄程度以及超声心动图资料。结果 SCH组女性患者比例高于正常组,SCH组患者甘油三酯(TG)水平高于正常组(P<0.05)。总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高密度值蛋白胆固醇(HDL-C)水平,血压、游离三碘甲状腺原氨酸(FT3)、三碘甲状腺原氨酸(T3)、游离甲状腺素(FT4)水平无差异,而肌酐、胱抑素-C、同型半胱氨酸、甲状腺素(T4)、促甲状腺激素(TSH)水平高于正常组(P<0.05)。SCH组患者冠心病比例高于正常组且冠状动脉狭窄单支、双支、三支或左主干病变发生率均高于正常组(P<0.05)。SCH组左室舒张末期容积大于正常组(P<0.05)。结论 SCH患者冠心病发生率高于甲状腺功能正常患者。 Objective To investigate the relationship between subclinical hypothyroidism (SCH) and coronary heart disease. Methods 211 cases of coronary heart disease and selective coronary angiography were selected. They were included in 48 cases of normal thyroid function group and 163 cases of SCH group. According to coronary angiography results were included in the coronary angiography negative group, single coronary artery disease, double-vessel disease, three or left main disease group. The basic data of each group were compared, the degree of coronary artery stenosis and echocardiographic data. Results The proportion of female patients in SCH group was higher than that in normal group. The triglyceride (TG) level in SCH group was higher than that of normal group (P <0.05). The levels of TC, LDL-C and HDL-C, blood pressure, free triiodothyronine (FT3), triiodothyronine (T3) (P <0.05). The levels of creatinine, cystatin C, homocysteine, thyroid hormone (T4) and thyroid stimulating hormone (TSH) were higher than those in normal group (P <0.05). The incidence of coronary artery disease in SCH group was higher than that in normal group, and the incidence of coronary artery stenosis in single, double, triple or left main trunk was higher than that in normal group (P <0.05). The left ventricular end diastolic volume in SCH group was higher than that in normal group (P <0.05). Conclusions The incidence of coronary heart disease in patients with SCH is higher than that in patients with normal thyroid function.