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Regulations for the Supervision and Administration of Cosmetics was promulgated by the State Council on June 29, 2020 and will take effect on January 1, 2021. Compared with the previous Regulations on Health Supervision of Cosmetics, there are more items proposed for the safety of cosmetics. In this paper, the main changes of the safety supervision of cosmetics by comparing the “new” and “old” regulations were summarized with the potential influences on different groups (government, cosmetic enterprises and consumers) discussed. The important laws and regulations on cosmetic safety and risk assessment in China with recently added in vitro testing methods were summarized and the principal theory of cosmetic quantitative risk assessment was introduced.