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目的了解抗感染药物不良反应(ADR)的发生特点和规律,为临床合理用药提供参考。方法收集我院2010年1月至2011年12月上报的440例抗感染药物ADR报表进行回顾性分析。结果 440例抗感染药物的ADR涉及11大类,共60种药品,其中头孢菌素类ADR报告例数最多,为132例(30.00%)。ADR临床表现主要为皮肤及附件反应(52.91%)。给药途径以静脉滴注为主(78.86%)。440例ADR中有3例属于新的严重不良反应,同时有3例不良反应留下后遗症。结论临床应重视抗感染药物的合理使用,加强用药监测和报告,以预防和减少ADR的发生。
Objective To understand the characteristics and rules of anti-infective drug adverse reactions (ADRs) and provide references for clinical rational drug use. Methods A retrospective analysis of 440 cases of ADRs reported in our hospital from January 2010 to December 2011 was conducted. RESULTS: The ADRs of 440 anti-infective drugs involved 11 categories and a total of 60 drugs. Among them, the highest reported cases of cephalosporin ADR were 132 cases (30.00%). The clinical manifestations of ADR were mainly skin and accessory reactions (52.91%). The main route of administration to intravenous drip (78.86%). Three of the 440 ADR cases were classified as new serious adverse reactions, while three adverse reactions left sequelae. Conclusion Clinical should pay attention to the rational use of anti-infective drugs, strengthen drug monitoring and reporting to prevent and reduce the occurrence of ADR.