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目的:研究米非司酮配伍米索前列醇行早、中孕期引产的效果。方法:早、中孕期引产孕妇80例根据随机数字表法分为治疗组与对照组各40例,对照组给予常规剂量米非司酮配伍米索前列醇引产,治疗组给予小剂量上述药物引产。结果:治疗组的引产成功率为95.0%,对照组的引产成功率为97.5%。治疗组的恶心呕吐、腹泻、发热等不良反应发生率明显低于对照组,对比差异明显(P<0.05)。结论:小剂量米非司酮配伍米索前列醇行早、中孕期引产能在保持高引产成功率的基础上,降低不良反应。
Objective: To study the effect of mifepristone and misoprostol on induction of labor in early and middle trimester. Methods: Eighty pregnant women with induced labor during early and middle trimester were divided into treatment group (40 cases) and control group (40 cases) according to random number table. Patients in control group were given mifepristone with misoprostol and induction group. Mice in treatment group were given low doses of the above drugs . Results: The success rate of induction of labor was 95.0% in the treatment group and 97.5% in the control group. The incidence of nausea and vomiting, diarrhea, fever and other adverse reactions in the treatment group was significantly lower than that in the control group, with significant difference (P <0.05). Conclusion: Mifepristone combined with misoprostol in early and middle-term pregnant women can reduce the adverse reactions on the basis of keeping the successful rate of induction.