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观察心外左向右分流(LRS)、低压性缺氧(HH)及分流附加低压性缺氧(SHH)所致肺动脉高压(PH)大鼠血浆肾素活性(RA)、血管紧张素Ⅰ(AⅠ)、血管紧张素Ⅱ(AⅡ)浓度及AⅠ转变为AⅡ的比率和精氨酸加压素(AVP)的改变。结果LRS组及SHH大鼠RA呈升高趋势,但与对照组比较无显著差异(P>0.05);HH组无改变。LRS组AⅡ浓度显著高于对照组(P<0.05),AⅠ及AⅡ/AⅠ亦呈升高趋势,但未达显著差异(P>0.05);而HH及SHH组较LRS组降低,尤以HH组为著。LRS大鼠AVP显著升高(P<0.05);其他组也呈升高趋势,但未达统计学显著意义(P>0.05)。本文对体液因素在PH形成中的作用进行了分析。
To observe the changes of plasma renin activity (RA), angiotensin Ⅰ (superscript +) and interleukin-6 (IL-6) in left pulmonary artery (PH) rats undergoing left heart to heart (LRS), hypobaric hypoxia (HH) and shunting hypoxia hypoxia (SHH) AⅠ), the concentration of angiotensin Ⅱ (AⅡ) and the ratio of AⅠ to AⅡ and the changes of arginine vasopressin (AVP). Results The RA of LRS group and SHH rats showed an increasing trend, but there was no significant difference between the two groups (P> 0.05). There was no change in HH group. The concentration of AⅡ in LRS group was significantly higher than that in control group (P <0.05), AⅠ and AⅡ / AⅠ also increased, but not significantly different (P> 0.05), while HH and SHH groups were lower than LRS group, especially HH For the group. The AVP level in LRS rats increased significantly (P <0.05). The other groups also showed an increasing trend, but the difference was not statistically significant (P> 0.05). In this paper, the role of humoral factors in the formation of PH was analyzed.