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目的:研究氟比洛芬酯超前镇痛在妇科腹腔镜手术中的应用。方法:60例ASAⅠ～Ⅱ级择期行妇科手术的患者,随机分为三组,每组20例。对照组(C组)麻醉诱导前和术毕患者拔管清醒即刻静脉缓慢注射脂肪乳5mL;超前镇痛组(P组)麻醉诱导前静脉缓慢注射氟比洛芬酯5mL,术毕患者拔管清醒即刻静脉缓慢注射脂肪乳5mL;常规镇痛组(R组)麻醉诱导前静脉缓慢注射脂肪乳5mL,术毕患者拔管清醒即刻静脉缓慢注射氟比洛芬酯5mL。分别记录拔管清醒即刻、1、2、4、6、12、24h的视觉模拟评分法(VAS)的评分;记录24小时追加镇痛药情况;并统计24h内不良反应。结果:术后P组1、2、4、6、12h的VAS评分明显低于C组同时点VAS评分(P<0.05);而P组1、2、4、6h的VAS评分明显低于R组同时点VAS评分(P<0.05)。结论:氟比洛芬酯可安全地用于妇科腹腔镜手术镇痛,而使用超前镇痛可提供更好的术后镇痛效果。
Objective: To study the application of flurbiprofen axetil analgesia in gynecological laparoscopic surgery. Methods: Sixty patients with ASA Ⅰ ~ Ⅱ elective gynecological surgery were randomly divided into three groups of 20 cases each. Control group (C group) before anesthesia induction and surgery patients extubation immediately intravenous injection of fat emulsion 5mL slow; preemptive analgesia group (P group) anesthesia before induction of slow intravenous injection of flurbiprofen axetil 5mL, after extubation 5mL of fat emulsion was injected into conscious and immediate vein slowly. In the routine analgesia group (R group), 5mL of fat emulsion was slowly injected into the vein before anesthesia induction, and 5mL of flurbiprofen axetil was slowly injected intravenously immediately after extubation. The scores of visual analogue scale (VAS) at 1,2,4,6,12,24h immediately after extubation were awake were recorded respectively. The analgesic was recorded 24 hours later, and the adverse reaction was counted within 24 hours. Results: The VAS score at 1, 2, 4, 6, 12 h after PCI in P group was significantly lower than that in C group (P <0.05), while the VAS scores at 1, 2, Group at the same time point VAS score (P <0.05). Conclusion: Flurbiprofen axetil can be safely used in gynecological laparoscopic surgery for pain relief, and the use of advanced analgesia provides better postoperative analgesia.