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喘可宁栓是一种用于治疗止咳、祛痰、平喘及慢性气管炎的新药。由于是栓剂,具有吸收慢,副作用小的优点,但主要成分均为剧毒药,故有必要控制其质量,在使用时达到安全有效的目的,本文对该制剂的成分进行了分离鉴定并制定了含量测定方法。喘可宁栓是氢溴酸东莨菪碱,硫酸阿托品,盐酸麻黄碱及扑尔敏等四种成分组成,由于各组分的剂量悬殊,性质互相干扰,再加上栓剂基质的影响,给分离鉴定带来一定的难度,我们通过一系列的摸索,找出了灵敏度高,简便,快速的方法。
Chuankunning suppository is a new medicine for treating cough, expectorant, asthma and chronic bronchitis. Because it is a suppository, it has the advantages of slow absorption and small side effects, but the main components are highly toxic drugs, so it is necessary to control the quality of the suppository to achieve safe and effective purposes. In this paper, the components of the preparation were identified and formulated The content determination method. Chuankunning suppository is scopolamine hydrobromide, atropine sulfate, ephedrine hydrochloride and chlorpheniramine and other four components, due to the various components of the dose disparity, the nature of mutual interference, coupled with the impact of suppository matrix to the identification of the separation zone To a certain degree of difficulty, we through a series of exploration, to find a high sensitivity, simple and fast method.