糖尿病周围神经病变(DPN)作为糖尿病的一个重要并发症,60%~70%的糖尿病患者可在疾病发展过程中出现周围神经损害[1]。发病与代谢紊乱、微血管病变及山梨醇旁路代谢增强等因素有关,临床症状常以对称性肢体疼痛、麻木及感觉减退为主要表现。感觉神经病变为最常见的DPN类型,目 Diabetic peripheral neuropathy (DPN) is an important complication of diabetes mellitus, and 60% to 70% of diabetic patients develop peripheral nerve damage during the development of the disease [1]. Incidence and metabolic disorders, microangiopathy and sorbitol bypass metabolism and other factors, the clinical symptoms often symmetrical limb pain, numbness and sensory loss as the main performance. Sensory neuropathy is the most common type of DPN, head and neck