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既往对疱疹样皮炎(DH)和腹腔疾病(CD)伴肾小球肾炎已有报道。作者发现一些DH和CD患者具有典型IgA肾小球肾炎(IgAGN)表现。由于DH和CD常伴有其他免疫疾病且有循环IgA免疫复合物。实验动物表明口服麦Ⅱ和麦胶可引起IgAGN。提示麦胶引起肠病与Ⅰ-gAGN间有一定相关。本文旨在研究CD与肾小球免疫病理和血清学之间关系。 25例CD患者,女性20例,男性5例,年龄自17-63岁(平均42岁),均无肾脏病病史。患者均经小肠活检诊断。18例空肠粘膜绒毛全部或次全萎缩,7例呈部分萎缩。所有患者均接受正常的含麦胶饮食。患者均作肾穿刺活检,并取前臂皮肤作活检。免疫荧光检查(IF)包括抗IgG,IgA,IgM,C_3,Ciq和纤维蛋白元。空肠活检标本作HE染色,按粘膜绒毛的平均高度
Previous studies have reported on herpetic-like dermatitis (DH) and celiac disease (CD) with glomerulonephritis. The authors found that some DH and CD patients had typical IgA glomerulonephritis (IgAGN) manifestations. Because DH and CD are often accompanied by other immune diseases and have circulating IgA immune complexes. Experimental animals show that orally administered wheat Ⅱ and wheat glue can cause IgAGN. Tip gingivitis caused by enteropathy and Ⅰ-gAGN between a certain correlation. This article aims to study the relationship between CD and glomerular immunopathology and serology. Twenty-five CD patients, 20 females and 5 males, aged from 17 to 63 (mean, 42 years), had no history of nephrotic disease. Patients were diagnosed by intestinal biopsy. 18 cases of jejunal mucosal villi all or subtotal atrophy, 7 cases showed partial atrophy. All patients received normal gluten-containing diet. All patients underwent kidney biopsy and forearm skin biopsy. Immunofluorescence (IF) includes anti-IgG, IgA, IgM, C_3, Ciq, and fibrin. Jejunal biopsy specimens were stained for HE by the average height of mucosal villi