目的　研究白色念珠菌胃癌株蛋白酶活性与其毒力的关系。方法　用牛乳琼脂平板筛选产酶株并测定其活力 ,用产酶株菌悬液尾静脉注射感染小鼠 ,以其平均存活时间 (d)评价菌株毒力。结果　来自胃癌患者的白色念珠菌 10 0 %产生蛋白酶 ,以癌组织中的菌株酶活力最强 ,均对小鼠有毒力 ,可在 2～ 8d致参试小鼠 10 0 %死亡。结论　白色念珠菌胃癌株均分泌蛋白酶 ,作为白色念珠菌的重要致病因素之一 ,蛋白酶活力可作为判断其毒力的直接指标。 Objective To study the relationship between the protease activity of Candida albicans gastric carcinoma and its virulence. Methods The enzyme-producing strains were screened on the milk agar plate and their viability was determined. The infected mice were injected with the tail vein of the enzyme-producing bacterial suspension to evaluate the virulence of the strains with their average survival time (d). Results Candida albicans from patients with gastric cancer had 10 0% protease and the strongest enzyme activity in the cancer tissues, all of which were virulent to mice and could kill 10 0% of the tested mice from 2 to 8 days. Conclusions Candida albicans gastric carcinoma cell line secretes protease, which is one of the important virulence factors of Candida albicans. Protease activity can be used as a direct indicator to judge its virulence.