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本文论述了电子顺磁共振成像（ＥＰＲＩ）方法以及近年来该方法在生物医学研究领域的应用现状、存在问题与展望。目前适于生物样品的ＥＰＲＩ方法主要工作在Ｌ波段微波或射频波段。成像信号主要依赖于外源性稳定的自旋标记物、探针或ＮＯ自旋加合物。成像多以小体积动物（大鼠或小鼠）为模型。可研究某些病理、生理过程及体内药物代谢特性。成像对象涉及心脏、脑、肝、肾、胃、胸腔、腹腔及皮肤等。体内成像分辨率可小于０．２ｍ ｍ 。实现对生物体内源性顺磁物质的成像及进一步加大成像体积是该领域要解决的主要问题。
This paper discusses the methods of electronic paramagnetic resonance imaging (EPRI) and its applications in biomedical research in recent years, problems and prospects. The current EPRI method for biological samples mainly works in the L band microwave or radio frequency band. The imaging signal relies mainly on externally stable spin labels, probes or NO spin adducts. Imaging is mostly modeled on small animals (rats or mice). Can study some pathological, physiological processes and in vivo drug metabolism. Imaging objects related to the heart, brain, liver, kidney, stomach, chest, abdominal cavity and skin. In vivo imaging resolution can be less than 0.2m m. Realizing the imaging of the endogenous paramagnetic substance in the living body and further increasing the imaging volume are the main problems to be solved in this field.