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为探讨上皮膜抗原（EMA）免疫标记与膀胱肿瘤生物学行为的关系，采用LSAB免疫组织化学技术对54例膀胱肿瘤石蜡切片标本进行研究。研究发现随着肿瘤分级和分期的增加，EMA阳性细胞率明显减低（P＜0．01）。EMA的标记表达率在初发与复发及单发与多发肿瘤之间有极显著性差异（均P＜0．01）。尽管EMA在男性和＞50岁患者中表达率较低，但与相应女性和≤50岁患者相比无显著性差异（P＞0．05）。研究表明，EMA与膀胱肿瘤生物学行为关系极密切，可作为判断膀胱肿瘤恶性程度和预后的重要标记物。
To investigate the relationship between epithelial membrane antigen (EMA) immunological markers and the biological behavior of bladder tumors, LSAB immunohistochemistry was used to study 54 bladder tumor paraffin sections. The study found that as the tumor grade and staging increased, the positive rate of EMA cells was significantly reduced (P <0.01). There was a significant difference in the expression rate of EMA between primary and recurrent as well as single and multiple tumors (all P <0.01). Although EMA was less expressed in men and> 50 years of age, there was no significant difference (P> 0.05) between EMA and corresponding women and ≤50 years of age. Studies have shown that, EMA and biological behavior of bladder tumors are closely related, can be used as an important marker to determine the degree of malignancy and prognosis of bladder cancer.