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目的探讨饮水型氟病区儿童骨质疏松与尿氟之间的关系。方法于2011年4月,选择固原市氟病区南屯村、马园村、南源村作为调查点,以非氟病区开城村作为对照村;在每村选择50名在当地出生的8～12岁在校小学生(2～6年级各选10名,男女各半)共200名。测定水氟浓度和小学生尿氟与骨密度。结果氟病村的水氟浓度均高于对照村,且均发现有小学生发生骨质疏松。小学生骨质疏松发生率(y)与尿氟浓度(x)的拟合方程为y=1/(1+e3.407-0.369x),尿氟的基准剂量和基准剂量下限分别为2.59、1.67 mg/L。结论本次调查的固原市氟病区小学生骨质疏松的发生率随着尿氟的升高而上升。
Objective To investigate the relationship between osteoporosis and urinary fluoride in children with drinking-water fluorosis. Methods In April 2011, Nantun Village, Mayuan Village and Nanyuan Village were selected as the investigation points in Kaifu District, Guyuan City, and Kaicheng Village was selected as the control village in non-fluoro-disease area. Fifty locally-born 8 ~ 12-year-old primary school students (2 ~ 6 grade each of 10, half male and female) a total of 200. Determination of water fluoride concentration and urinary fluoride and bone mineral density in primary school students. Results Fluorosis village water fluoride concentrations were higher than the control village, and found that primary school students with osteoporosis. The fitting equation of primary school student’s incidence of osteoporosis (y) and urinary fluoride concentration (x) was y = 1 / (1 + e3.407-0.369x). The baseline and baseline doses of urinary fluoride were 2.59 and 1.67 respectively mg / L. Conclusions The prevalence of osteoporosis among primary school students in Guiyang fluorosis area in this survey increased with the increase of urinary fluoride.